Level 1 study comparing 15-year outcomes of interosseous bone marrow concentrate injection (IO BMAC) vs total knee replacement (TKA) surgery for knee osteoarthritis.
In a landmark 15-year study of 140 patients between the ages of 65 and 90, researchers compared the outcomes of Total Knee Arthroplasty (TKA) in one knee against subchondral Bone Marrow Concentrate (BMC) injections in the other.
Comparison of ultrasound-guided (USG) versus palpation-guided AC joint injections: 2 cadaveric studies.
Two cadaveric studies show that ultrasound-guided (USG) injections significantly improve acromioclavicular (AC) joint placement accuracy.
Comparison of ultrasound-guided versus blind glenohumeral injections: a cadaveric study.
In a controlled study involving 80 cadaveric shoulder injections, experienced surgeons compared the efficacy of two guidance methods using a posterior approach.
Study evaluating the therapeutic impact of combined BMC and PRP injections on moderate-to-severe osteoarthritis.
This 2016 retrospective study of 125 patients found that a single ultrasound-guided Bone Marrow Concentrate (BMC)injection followed by a PRP booster at eight weeks significantly reduced median pain by 71.4% in patients with moderate-to-severe osteoarthritis.
Study evaluating the efficacy of bone marrow concentrate (BMC) in treating hip osteoarthritis.
This pilot study of 18 hips from 16 patients demonstrates that a single intra-articular injection of Bone Marrow Concentrate (BMC) serves as a safe biological bridge for symptomatic hip osteoarthritis.
Study comparing 15-year outcomes of interosseous vs. intra-articular bone marrow concentrate for knee osteoarthritis.
A 15-year randomized trial of 60 patients with bilateral knee osteoarthritis compared the long-term outcomes of interosseous (IO) vs. intra-articular (IA) bone marrow concentrate injections.
Study assessing platelet concentration effects on platelet-rich plasma (PRP) treatment outcomes in knee osteoarthritis.
In this cohort study of 253 patients with knee osteoarthritis, researchers found that platelet concentration positively correlated with clinical improvements in KOOS and IKDC scores over a 12-month follow-up.
Study looking at efficacy of MFAT, BMC, PRP and hyaluronic acid for treatment of knee osteoarthritis.
This 2021 network meta-analysis of 43 randomized controlled trials concluded that adipose-derived mesenchymal signaling cells (MFAT) provided the highest level of pain relief, while leukocyte-poor platelet-rich plasma (LP-PRP) was the most effective for restoring joint function.
Study comparing efficacy of platelet-rich plasma (PRP) against placebo, hyaluronic acid and corticosteroid.
This meta-analysis of 34 randomized controlled trials concludes that Platelet-Rich Plasma (PRP) injections for knee osteoarthritis provide statistically and clinically significant improvements in pain and function compared to placebo, hyaluronic acid, and corticosteroids.
Study comparing efficacy of corticosteroid, hyaluronic acid and platelet-rich plasma (PRP) injections for knee osteoarthritis.
This 2024 meta-analysis of 35 clinical trials concludes that corticosteroid (CS) injections for knee osteoarthritis offer benefits comparable to other injectables only in the very short term (≤ 6 weeks).